Stage 2 Breast Cancer Diagnosis, Treatment, and Survival Rate

Survival rate for women with stage 2 breast cancer is around 93% with treatment

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Stage 2 breast cancer survival rates are high and with the right treatment, the outlook is very good. Stage 2 breast cancer means your tumor is at least 1 centimeter (cm) in size and has spread to lymph nodes.

Treatment of stage 2 breast cancer usually includes surgery (either a lumpectomy or mastectomy), and adjuvant chemotherapy (therapy after the initial treatment) is often recommended. Radiation therapy is needed after a lumpectomy, but may or may not be needed after a mastectomy.

This article discusses the diagnosis and treatment of stage 2 breast cancer. It also looks at survival rates for people who are diagnosed at this stage.

stage 2 breast cancer
 Verywell / Jessica Olah

Overview

Stage 2 breast cancer is considered invasive, meaning that cancer cells have broken out of the ducts or lobules of the breast. This is not the same as metastatic (stage 4) breast cancer. It means that abnormal cells have passed through a thin layer of tissue called the basement membrane and have the potential to spread.

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Breast Cancer Treatment Options

Staging

Cancers are scored and divided into stages by the TNM system. Stage 2 cancer can be either 2A or 2B.

In this system:

  • T stands for tumor size: In stage 2, the T score can range from 0 to 3. T0 means that a tumor cannot be detected in the breast. T1 includes tumors that have a diameter of 2 cm or less (an inch or less). T2 includes tumors that are between 2 and 5 cm in diameter. T3 includes tumors larger than 5 cm in diameter.
  • N stands for lymph node involvement: Stage 2 can be either 0 or 1. N0 (N-zero) would mean that cancer has not spread to any lymph nodes. N1mi describes cancers that have spread to lymph nodes but the spread can only be detected microscopically (micrometastases). N1 is used to describe tumors that have spread to at least one lymph node near the tumor.
  • M stands for metastasis: All stage 2 cancer is M0, meaning no metastases are present.
Stage 2 Breast Cancers
Stage 2A: T0, N1, M0 No tumor has been found in breast tissue, but cancer cells have lodged in lymph nodes near your breast.
Stage 2A: T1, N1, M0 You have a tumor of 2 cm or smaller that has spread to at least one lymph node. —OR— Your tumor has invaded nearby tissue and has spread to at least one lymph node.
Stage 2A: T2, N0, M0 Your tumor is over 2 cm and up to 5 cm, but hasn't affected any lymph nodes.
Stage 2B: T2, N1, M0 Your tumor is bigger than 2 cm and less than 5 cm, and has involved nearby lymph nodes.
Stage 2B: T3, N0, M0 Your tumor is more than 5 cm, but has not reached your chest wall or skin, and has not traveled to any lymph nodes.

Treatment

Your treatment can include a combination of approaches. Treatment options include:

Local Treatments

Surgical choices will include a lumpectomy or a mastectomy. If you opt for a mastectomy, it will also be important to consider the pros and cons of having a single vs. a double mastectomy.

Radiation therapy may be used after a lumpectomy to mitigate the risk of cancer cells recurring in the same breast or nearby lymph nodes. If radiation is recommended, that will affect the timing of any breast reconstruction that you may have.

After a mastectomy, an oncologist may determine that radiation is necessary if the tumor was larger than 5 cm, if there was lymph node involvement, or if cancer was found outside of surgical margins.

Systemic Treatments (Adjuvant)

These therapies will affect your whole body and will help prevent a recurrence. Depending on your age, general health, hormone receptor status, lymph node involvement, and HER2 testing results, you may be given:

With triple-negative breast cancer, immunotherapy can sometimes be part of systemic therapy. The drug Lynparza (olaparib), a PARP inhibitor, is now being used as part of systemic therapy to treat early-stage and metastatic HER2-negative breast cancer with a BRCA1 or BRCA2 mutation that has previously been treated with chemotherapy—either before or after surgery.

Neoadjuvant Treatment

Your oncologist may suggest systemic treatments before surgery to shrink the tumor. When this approach is successful, the smaller tumor can be removed and local treatment may be given if needed.

Some tumors don't respond well to pre-treatment; when that happens, a mastectomy will be necessary. You may then consider breast reconstruction.

You may spend three to 18 months or longer in the active treatment of stage 2 breast cancer. It may range from surgery and six weeks of radiation to a full array of chemo, radiation, and biologic therapies.

If the tumor is estrogen receptor-positive, hormone therapy is usually prescribed for five to 10 years. For those who are postmenopausal, bisphosphonate therapy may be recommended as well to reduce the risk of recurrence. If the cancer is HER2-positive, targeted therapy is often used prior to surgery.

Survival Rates for Stage 2 Breast Cancer

Stage 2 breast cancer survival rates are high, but it is important to understand that the rates are not a direct indication of how long you will live following the diagnosis and treatment of breast cancer. Rather, rates reflect how many people on average will be expected to survive for a given period of time.

The five-year survival rate for stage 2 breast cancer is 93% for women who have completed treatment. Women with stage 3 cancer have a five-year survival rate of 75%.

Treatments continue to improve over time, so you may have a longer-term estimated survival if you are newly diagnosed.

Is Stage 2 Breast Cancer Curable?

Stage 2 breast cancer is curable with the right treatment. Although recurrence is possible, the chances can be reduced with radiation treatment and appropriate follow-up care.

Follow-Up Care

After your treatment is completed, you will have a five-year minimum follow-up period with your oncologist; check-ups will take place every three then every six months.

During this time, you may need to take hormone therapy if your tumor was hormone-sensitive. Sometimes hormone therapy is recommended beyond five years for those with estrogen receptor-positive tumors.

If your tumor is estrogen-receptor positive, your oncologist may also recommend that you use bisphosphonate therapy if you are postmenopausal. Bisphosphonates are medications that are used for the treatment of osteoporosis, and they also may help reduce the chance that breast cancer will spread to bones (the most common site of metastases).

What are the chances of breast cancer recurrence after treatment for stage 2 breast cancer?

For women diagnosed with stage 2 breast cancer, the 15-year rate of local recurrence is about 16%.

Distant recurrence in those who had a mastectomy is most influenced by axillary lymph node involvement. When axillary lymph nodes are not cancerous, the recurrence rate is 6% in five years. When axillary lymph nodes are cancerous, the recurrence rate is 23% in five years with mastectomy but no radiation.

Unlike some cancers, routine scans are not usually done after primary treatment for stage 2 breast cancer has been completed. The reason for this, even though recurrence is a possibility, is that finding a recurrence early (before symptoms appear) does not improve survival. For those who have finished treatment, it's important to be familiar with the potential signs and symptoms of a recurrence and to contact your healthcare provider with any concerns.

After five years, you may only need to see your oncologist annually, but these visits most often continue throughout your life. Check-ups are important to make sure that recovery is going smoothly and that treatment for recurrence won't be needed. 

Breast Cancer Healthcare Provider Discussion Guide

Get our printable guide for your next healthcare provider's appointment to help you ask the right questions.

Doctor Discussion Guide Woman

Coping

If you've been recently diagnosed with stage 2 breast cancer, you may feel overwhelmed.

There is a multitude of resources for receiving support and learning more about your diagnosis. Ask for help and reach out to your loved ones. Consider becoming involved in one of the active breast cancer support groups or support communities available.

Most importantly, learn how to be your own advocate in your cancer care. Cancer treatments are changing rapidly, and it's important to understand the options available so you can be an active member of your cancer treatment team.

Summary

If you've been diagnosed with stage 2 breast cancer, the outlook is very good. You are more likely to have chemotherapy and/or radiation therapy than if your tumor was stage 1, but these tumors are still very treatable.

If your cancer is successfully treated, you will need follow-up care, which includes treatment that decreases the chances of a cancer recurrence. 

23 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Akram M, Iqbal M, Daniyal M, Khan AU. Awareness and current knowledge of breast cancerBiol Res. 2017;50(1):33.doi:10.1186/s40659-017-0140-9

  2. Marta GN, Poortmans PM, Buchholz TA, Hijal T. Postoperative radiation therapy after nipple-sparing or skin-sparing mastectomy: A survey of European, North American, and South American practices. Breast J. 2017;23(1):26-33. doi:10.1111/tbj.12683

  3. Cancer: What do the codes in the doctor's letter mean? InformedHealth.org [Internet].

  4. Giuliano AE, Connolly JL, Edge SB, et al. Breast cancer-major changes in the American Joint Committee on Cancer Eighth Edition Cancer Staging Manual. CA Cancer J Clin. 2017;67(4):290-303. doi:10.3322/caac.21393

  5. Koh J, Kim MJ. Introduction of a New Staging System of Breast Cancer for Radiologists: An Emphasis on the Prognostic StageKorean J Radiol. 2019;20(1):69–82. doi:10.3348/kjr.2018.0231

  6. Sopik V, Narod SA. The relationship between tumour size, nodal status and distant metastases: on the origins of breast cancerBreast Cancer Res Treat. 2018;170(3):647–656. doi:10.1007/s10549-018-4796-9

  7. Yao K, Sisco M, Bedrosian I. Contralateral prophylactic mastectomy: current perspectivesInt J Womens Health. 2016;8:213–223. doi:10.2147/IJWH.S82816

  8. Lee SH, Kim YS, Han W, et al. Tumor growth rate of invasive breast cancers during wait times for surgery assessed by ultrasonographyMedicine (Baltimore). 2016;95(37):e4874. doi:10.1097/MD.0000000000004874

  9. Kunte S, Abraham J, Montero AJ. Novel HER2-targeted therapies for HER2-positive metastatic breast cancer. Cancer. 2020;126(19):4278-4288. doi:10.1002/cncr.33102

  10. Breastcancer.org. Lynparza.

  11. Teven CM, Schmid DB, Sisco M, Ward J, Howard MA. Systemic Therapy for Early-Stage Breast Cancer: What the Plastic Surgeon Should KnowEplasty. 2017;17:e7. PMID: 28293332

  12. Wimmer K, Strobl S, Bolliger M, et al. Optimal duration of adjuvant endocrine therapy: how to apply the newest dataTher Adv Med Oncol. 2017;9(11):679–692. doi:10.1177/1758834017732966

  13. Giaquinto AN, Sung H, Miller KD, et al. Breast cancer statistics, 2022. CA Cancer J Clin. 2022;72(6):524-541. doi:10.3322/caac.21754

  14. Bodai BI, Tuso P. Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendationsPerm J. 2015;19(2):48–79. doi:10.7812/TPP/14-241

  15. Gupta S, Singh M, Vora A, et al. Practical consensus recommendations on duration of adjuvant hormonal therapy in breast cancerSouth Asian J Cancer. 2018;7(2):142–145. doi:10.4103/sajc.sajc_122_18

  16. Wang L, Zhang S, Wang X. The metabolic mechanisms of breast cancer metastasis. Front Oncol. 2021;10:602416. doi:10.3389/fonc.2020.602416

  17. Sopik V, Nofech-Mozes S, Sun P, Narod SA. The relationship between local recurrence and death in early-stage breast cancer. Breast Cancer Res Treat. 2016;155(1):175-85. doi:10.1007/s10549-015-3666-y

  18. Carlson RW. Chapter 67: Surveillance of patients following primary therapy. In Harris JR, Lippman ME, Morrow M, Osborne CK. Diseases of the Breast, 5th edition. Lippincott Williams and Wilkins, 2014.

  19. American Cancer Society. Follow-up care after breast cancer treatment.

  20. Urquhart R, Lethbridge L, Porter GA. Patterns of cancer centre follow-up care for survivors of breast, colorectal, gynecologic, and prostate cancerCurr Oncol. 2017;24(6):360–366. doi:10.3747/co.24.3627

  21. Su JA, Yeh DC, Chang CC, et al. Depression and family support in breast cancer patientsNeuropsychiatr Dis Treat. 2017;13:2389–2396. doi:10.2147/NDT.S135624

  22. Hagan TL, Medberry E. Patient Education vs. Patient Experiences of Self-advocacy: Changing the Discourse to Support Cancer SurvivorsJ Cancer Educ. 2016;31(2):375–381. doi:10.1007/s13187-015-0828-x

  23. Scharl A, Kühn T, Papathemelis T, Salterberg A. The right treatment for the right patient - Personalised treatment of breast cancerGeburtshilfe Frauenheilkd. 2015;75(7):683–691. doi:10.1055/s-0035-1546270

Additional Reading

By Lynne Eldridge, MD
 Lynne Eldrige, MD, is a lung cancer physician, patient advocate, and award-winning author of "Avoiding Cancer One Day at a Time."